TargetMol

Lumiracoxib

Product Code:
 
TAR-T6574
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6574-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T6574-10mg10mg£111.00
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TAR-T6574-25mg25mg£128.00
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TAR-T6574-50mg50mg£148.00
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TAR-T6574-100mg100mg£172.00
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TAR-T6574-200mg200mg£215.00
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This product comes from: United States.
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Further Information

Bioactivity:
Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
CAS:
220991-20-8
Formula:
C15H13ClFNO2
Molecular Weight:
293.72
Pathway:
Neuroscience; Immunology/Inflammation
Purity:
0.9664
SMILES:
Cc1ccc(Nc2c(F)cccc2Cl)c(CC(O)=O)c1
Target:
COX

References

Jiao W, Zhao X, Wu G, et al. Bioactivation of Lumiracoxib in Human Liver Microsomes: Formation of GSH?and Amino Adducts Through Acyl Glucuronide[J]. Drug Testing and Analysis. 2020, 12(6): 827-835. Esser R, et al. Br J Pharmacol, 2005, 144(4), 538-550. Jiao W, Zhao X, Wu G, et al. Bioactivation of Lumiracoxib in Human Liver Microsomes: Formation of GSH?and Amino Adducts Through Acyl Glucuronide. Drug Testing and Analysis. 2020, 12(6): 827-835. Sun J, Zhang L, Zhang L, et al. A validated UHPLC?MS/MS method for simultaneous determination of lumiracoxib and its hydroxylation and acyl glucuronidation metabolites in rat plasma: Application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis. 2021, 201: 114105. Sun J, Zhang L, Zhang L, et al. A validated UHPLC-MS/MS method for simultaneous determination of lumiracoxib and its hydroxylation and acyl glucuronidation metabolites in rat plasma: application to a pharmacokinetic study[J]. Journal of Pharmaceutical and Biomedical Analysis. 2021: 114105. Sun J, Zhang L, Zhang L, et al. A validated UHPLC-MS/MS method for simultaneous determination of lumiracoxib and its hydroxylation and acyl glucuronidation metabolites in rat plasma: application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis. 2021: 114105.