TargetMol

Halobetasol (propionate)

Product Code:
 
TAR-T6529
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6529-10mg10mg£103.00
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Quantity:
TAR-T6529-1mL1 mL * 10 mM (in DMSO)£107.00
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Quantity:
TAR-T6529-50mg50mg£130.00
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Quantity:
TAR-T6529-100mg100mg£164.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Halobetasol Propionate is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.
CAS:
66852-54-8
Formula:
C25H31ClF2O5
Molecular Weight:
484.96
Pathway:
Metabolism
Purity:
0.9985
SMILES:
CCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CCl
Target:
Phospholipase

References

Mohandas S, et al. Indian J Dermatol Venereol Leprol, 2009, 75(2), 186-187.