TargetMol

CYC-116

Product Code:
 
TAR-T6458
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6458-5mg5mg£111.00
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Quantity:
TAR-T6458-1mL1 mL * 10 mM (in DMSO)£118.00
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TAR-T6458-10mg10mg£128.00
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TAR-T6458-25mg25mg£189.00
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TAR-T6458-50mg50mg£271.00
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Quantity:
TAR-T6458-100mg100mg£432.00
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Further Information

Bioactivity:
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.
CAS:
693228-63-6
Formula:
C18H20N6OS
Molecular Weight:
368.46
Pathway:
Chromatin/Epigenetic; MAPK; Tyrosine Kinase/Adaptors; Cell Cycle/Checkpoint; Angiogenesis; PI3K/Akt/mTOR signaling
Purity:
0.966
SMILES:
Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Target:
VEGFR; FLT; CDK; S6 Kinase; Aurora Kinase

References

Wang S, et al. J Med Chem. 2010, 53(11), 4367-4378.