TargetMol

CRT0044876

Product Code:
 
TAR-T6456
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6456-10mg10mg£102.00
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Quantity:
TAR-T6456-25mg25mg£121.00
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TAR-T6456-50mg50mg£139.00
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TAR-T6456-100mg100mg£157.00
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Quantity:
TAR-T6456-200mg200mg£179.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
CAS:
6960-45-8
Formula:
C9H6N2O4
Molecular Weight:
206.157
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
OC(=O)c1cc2cccc([N+]([O-])=O)c2[nH]1
Target:
DNA/RNA Synthesis

References

Long K, Gu L, Li L, et al. Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer. Cell Death & Disease. 2021, 12(6): 1-15. Madhusudan S, et al. Nucleic Acids Res. 2005, 33(15), 4711-4724. Seo Y, et al. Cancer Res. 2009, 69(18, 7285-7293. Long K, Gu L, Li L, et al. Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer[J]. Cell Death & Disease. 2021, 12(6): 1-15.