TargetMol

β-Lapachone

Product Code:
 
TAR-T6407
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T6407-10mg10mg£115.00
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TAR-T6407-1mL1 mL * 10 mM (in DMSO)£116.00
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TAR-T6407-25mg25mg£149.00
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TAR-T6407-50mg50mg£227.00
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TAR-T6407-100mg100mg£329.00
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TAR-T6407-200mg200mg£460.00
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Further Information

Bioactivity:
Beta-Lapachone is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
CAS:
4707-32-8
Formula:
C15H14O3
Molecular Weight:
242.274
Pathway:
Autophagy; Apoptosis; Metabolism; DNA Damage/DNA Repair
Purity:
0.9986
SMILES:
CC1(C)CCC2=C(O1)c1ccccc1C(=O)C2=O
Target:
IDO; Apoptosis; Topoisomerase; Autophagy

References

Wu L, Ma X, Yang X, et al. Synthesis and biological evaluation of ?-lapachone-monastrol hybrids as potential anticancer agents. European Journal of Medicinal Chemistry. 2020: 112594. Flick HE, et al. Int J Tryptophan Res. 2013, 6, 35-45. Li CJ, et al. J Biol Chem. 1993, 268(30), 22463-22468. Huang X, et al. Cancer Res. 2012, 72(12), 3038-3047. Wu L, Ma X, Yang X, et al. Synthesis and biological evaluation of ?-lapachone-monastrol hybrids as potential anticancer agents[J]. European Journal of Medicinal Chemistry. 2020: 112594. Planchon SM, et al. Cancer Res. 1995, 55(17), 3706-3711. Kung HN, et al. Am J Physiol Cell Physiol. 2008, 295(4), C931-943. Kim TW, et al. ?-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68(1):27-31.