TargetMol

Neflamapimod

Product Code:
 
TAR-T6089
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6089-5mg5mg£105.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6089-1mL1 mL * 10 mM (in DMSO)£108.00
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Quantity:
TAR-T6089-10mg10mg£127.00
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Quantity:
TAR-T6089-25mg25mg£173.00
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Quantity:
TAR-T6089-50mg50mg£245.00
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Quantity:
TAR-T6089-100mg100mg£330.00
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Quantity:
TAR-T6089-200mg200mg£458.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
VX-745, a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.
CAS:
209410-46-8
Formula:
C19H9Cl2F2N3OS
Molecular Weight:
436.26
Pathway:
MAPK; Autophagy
Purity:
0.9975
SMILES:
Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1
Target:
p38 MAPK; Autophagy

References

Alam JJ. Selective Brain-Targeted Antagonism of p38 MAPK? Reduces Hippocampal IL-1? Levels and Improves Morris Water Maze Performance in Aged Rats. J Alzheimers Dis. 2015;48(1):219-27. Decicco C, et al. American Chemical Society, 2000, IDDB3. Haddad JJ, Curr Opin Investig Drugs, 2001, 2(8), 1070-1076. Pradal J, et al. Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system. Eur J Pharm Biopharm. 2015 Jun;93:110-7. Duffy JP, et al. ACS Med Chem Lett, 2011, 2(10), 758-763. Hideshima T, et al. Blood, 2003, 101(2), 703-705. Salituro FG, et al. 27th National Medicinal Chemistry Symposium, 2000, June 16.