TargetMol

Azemiglitazone

Product Code:
 
TAR-T4639
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4639-5mg5mg£112.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T4639-1mL1 mL * 10 mM (in DMSO)£117.00
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Quantity:
TAR-T4639-10mg10mg£132.00
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Quantity:
TAR-T4639-25mg25mg£201.00
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Quantity:
TAR-T4639-50mg50mg£309.00
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Quantity:
TAR-T4639-100mg100mg£511.00
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Quantity:
TAR-T4639-500mg500mg£1,026.00
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Quantity:
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes.
CAS:
1133819-87-0
Formula:
C19H17NO5S
Molecular Weight:
371.41
Pathway:
PI3K/Akt/mTOR signaling; Metabolism
Purity:
0.996
SMILES:
COc1cccc(c1)C(=O)COc1ccc(CC2SC(=O)NC2=O)cc1
Target:
Mitochondrial Metabolism; mTOR

References

Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, Qi N, McDonald WG, Colca JR, Kletzien RF, Finck BN. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor ?-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48. Colca, J., McDonald, W., Cavey, G., Cole, S., Holewa, D., & Brightwell-Conrad, A. et al. (2013). Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)?Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins.?Plos ONE,?8(5), e61551. doi: 10.1371/journal.pone.0061551 Fukunaga T, Zou W, Rohatgi N, Colca JR, Teitelbaum SL. An insulin-sensitizing thiazolidinedione, which minimally activates PPAR?, does not cause bone loss. J Bone Miner Res. 2015 Mar;30(3):481-8. McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, Finck BN. Targeting the Mitochondrial Pyruvate Carrier Attenuates Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis. Hepatology. 2016 Dec 27. doi: 10.12002/hep.29025.