TargetMol

CMPI hydrochloride

Product Code:
 
TAR-T37293
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T37293-10mg10mg£301.00
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Further Information

Bioactivity:
Potent positive allosteric modulator of α4β2 nAChRs (EC50 values are 20 and 18 nM for rat and human, respectively). Selective for hα4β2 over hα3β2, hα3β4 and hα7. Inhibits (α4)2(β2)3, muscle-type and Torpedo nAChRs (IC50 values are 0.5, 0.7 and 0.2 μM, respectively), but not (α4)3(β2)2 receptors. Exhibits ability to photoincorporate into aliphatic and nucleophilic amino acid side chains.
CAS:
0
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Wang et al (2017) Unraveling amino acid residues critical for allosteric potentiation of (?4)3(?2)2-type nicotinic acetylcholine receptor responses. J.Biol.Chem. 292 9988 PMID:28446611 Albrecht et al (2008) Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant ?4?2 nicotinic acetylcholine receptor potentiators. Bioorg.Med.Chem.Lett. 18 5209 PMID:18789861 Hamouda (2016) Photolabeling a nicotinic acetylcholine receptor (nAChR) with an (?4)3(?2)2 nAChR-selective positive allosteric modulator. Mol.Pharmacol. 89 575 PMID:26976945