TargetMol

YNT-185 dihydrochloride

Product Code:
 
TAR-T37112
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.
CAS:
1804978-82-2
Formula:
C33H37N5O5S.2HCl
Molecular Weight:
688.66
Purity:
0.98
SMILES:
COC1=C(S(=O)(NC2=CC(NCCNC(C3=C(N(C)C)C=CC=C3)=O)=CC=C2)=O)C=C(C4=CC(C(N(C)C)=O)=CC=C4)C=C1.Cl.Cl

References

Irukayama-Tomobe et al (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 144 5731 PMID:28507129 Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 PMID:26267383