TargetMol

PDE4B-IN-2

Product Code:
 
TAR-T36832
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36832-1mg1mg£95.00
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TAR-T36832-5mg5mg£128.00
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TAR-T36832-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T36832-10mg10mg£161.00
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TAR-T36832-25mg25mg£254.00
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TAR-T36832-50mg50mg£369.00
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TAR-T36832-100mg100mg£550.00
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Quantity:
TAR-T36832-500mg500mg£1,083.00
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This product comes from: United States.
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Further Information

Bioactivity:
Potent and selective PDE4B inhibitor (IC50 = 15 nM); exhibits >100-fold selectivity for PDE4B over 4D. Regulates cAMP in inflammatory cells. Inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. Reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. Also exhibits antidepressant-like effects. Orally bioavailable.
CAS:
915082-52-9
Formula:
C19H18ClN3O2S
Molecular Weight:
387.88
Pathway:
Metabolism
Purity:
0.98
SMILES:
CCc1c(C)nc(nc1Nc1ccc(CC(O)=O)cc1)-c1ccc(Cl)s1
Target:
PDE

References

Zhang et al (2017) Comparison of the pharmacological profiles of selective PDE4B and PDE4D inhibitors in the central nervous system. Sci.Rep. 7 40115 PMID:28054669 Kenji Naganuma, et al. Discovery of selective PDE4B inhibitors. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3174-6. Wilson et al (2017) Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury. PLoS One 12 e0178013 PMID:28542295