TargetMol

Dihydrocapsaicin

Product Code:
 
TAR-T2163
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2163-10mg10mg£109.00
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TAR-T2163-25mg25mg£148.00
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TAR-T2163-50mg50mg£197.00
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TAR-T2163-100mg100mg£261.00
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Further Information

Bioactivity:
Dihydrocapsaicin is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an irritant. Capsaicin is found in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain pure dihydrocapsaicin. Dihydrocapsaicin represents about 10% of the compound present in commercial preparations purporting to be pure capsaicin, but it has about the same pungency as capsaicin. VR1 (vanilloid receptor 1) is a heat activated calcium ion channel which functions as a part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. The potency of dihydrocapsaicin at VR1 appears equivalent to capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic. Dihydrocapsaicin is an activator of VR1.
CAS:
19408-84-5
Formula:
C18H29NO3
Molecular Weight:
307.434
Pathway:
Membrane transporter/Ion channel;
Purity:
0.998
SMILES:
COc1cc(CNC(=O)CCCCCCC(C)C)ccc1O
Target:
TRP/TRPV Channel

References

1. Lawson T, et al. The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells. Cancer Lett. 1989 Nov 30;48(2):109-13. 2. Ram?rez-Romero R, et al. Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep. Regul Pept. 2 Jul 28;91(1-3):97-16.