TargetMol

GABOB (beta-hydroxy-GABA)

Product Code:
 
TAR-T21409
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21409-10mg10mg£140.00
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TAR-T21409-25mg25mg£185.00
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TAR-T21409-50mg50mg£259.00
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TAR-T21409-100mg100mg£409.00
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TAR-T21409-200mg200mg£559.00
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TAR-T21409-500mg500mg£708.00
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Quantity:
TAR-T21409-1g1g£1,008.00
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Further Information

Bioactivity:
GABOB is an anticonvulsant used to treat epilepsy. GABOB is an endogenous active metabolite, it is analogue to the neurotransmitter γ-aminobutyric acid (GABA), therefore may function as a neurotransmitter.
CAS:
7013-05-0
Formula:
C4H9NO3
Molecular Weight:
119.12
Purity:
0.98
SMILES:
NC[C@@H](O)CC(O)=O

References

1. Yamamoto I, Absalom N, Carland JE, Doddareddy MR, Gavande N, Johnston GA, Hanrahan JR, Chebib M. Differentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ?(1) receptors. ACS Chem Neurosci. 2012 Sep 19;3(9):665-73. Epub 2012 Apr 26. PubMed PMID: 23019493; PubMed Central PMCID: PMC3447397. 2. Du Z, Chen Z, Chen Z, Yu X, Hu W. Dirhodium-catalyzed enantioselective C-H insertion of N-(2-benzyloxyethyl)-N-(tert-butyl)diazoacetamide and its application for the synthesis of chiral GABOB. Chirality. 2004 Oct;16(8):516-9. PubMed PMID: 15290686. 3. Nakao J, Hasegawa T, Hashimoto H, Noto T, Nakajima T. Formation of GABOB from 2-hydroxyputrescine and its anticonvulsant effect. Pharmacol Biochem Behav. 1991 Oct;40(2):359-66. PubMed PMID: 1805240. 4. Banfi S, Fonio W, Allievi E, Pinza M, Dorigotti L. Cyclic GABA-GABOB analogues. IV. Activity on learning and memory. Farmaco Sci. 1984 Jan;39(1):16-22. PubMed PMID: 6538512.