TargetMol

PF-4693627

Product Code:
 
TAR-T16504
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16504-5mg5mg£412.00
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TAR-T16504-50mg50mg£1,476.00
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Quantity:
TAR-T16504-100mg100mg£2,207.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).
CAS:
1312815-93-2
Formula:
C26H29Cl2N3O3
Molecular Weight:
502.44
Pathway:
GPCR/G Protein; Immunology/Inflammation
Purity:
0.98
SMILES:
OC[C@H]1CCC[C@@H](C1)NC(=O)C1CCN(CC1)c1nc2cc(Cl)c(cc2o1)-c1ccc(Cl)cc1
Target:
Prostaglandin Receptor

References

1. Arhancet GB, et al. Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1114-9.