TargetMol

GSK319347A

Product Code:
 
TAR-T15558
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15558-5mg5mg£351.00
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TAR-T15558-50mg50mg£1,364.00
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Quantity:
TAR-T15558-100mg100mg£2,014.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK319347A is a TBK1 and IKKε dual inhibitor (IC50s: 93 nM and 469 nM, respectively). GSK319347A inhibits IKK2 (IC50: 790 nM).
CAS:
862812-98-4
Formula:
C22H19N3O5S2
Molecular Weight:
469.53
Pathway:
NF-κb
Purity:
0.98
SMILES:
COc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(s3)C#N)c2cc1OC
Target:
IκB/IKK

References

1. Johannes JW, et al. Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-? kinases. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1138-43. 2. Xie HZ, et al. Pharmacophore modeling and hybrid virtual screening for the discovery of novel I?B kinase 2 (IKK2) inhibitors. J Biomol Struct Dyn. 2011 Aug;29(1):165-79.