TargetMol

Raloxifene hydrochloride

Product Code:
 
TAR-T1549
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1549-25mg25mg£101.00
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TAR-T1549-50mg50mg£114.00
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TAR-T1549-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T1549-100mg100mg£136.00
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TAR-T1549-200mg200mg£168.00
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This product comes from: United States.
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Further Information

Bioactivity:
Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
CAS:
82640-04-8
Formula:
C28H28ClNO4S
Molecular Weight:
510.05
Pathway:
Metabolism; Autophagy; Endocrinology/Hormones; ; Neuroscience
Purity:
0.98
SMILES:
Cl.Oc1ccc(cc1)-c1sc2cc(O)ccc2c1C(=O)c1ccc(OCCN2CCCCC2)cc1
Target:
Estrogen Receptor/ERR; MAO; Estrogen/progestogen Receptor; Autophagy

References

1. Obach RS, et al. Drug Metab Dispos, 2004, 32(1), 89-97. 2. Yang NN, et al. Endocrinology, 1996, 137(5), 2075-2084. 3. Black LJ, et al. J Clin Invest, 1994, 93(1), 63-69. 4. Evans G, et al. Endocrinology, 1994, 134(5), 2283-2288. 5. Sato M, et al. FASEB J, 1996, 10(8), 905-912. 6. Liu Z, Wang Y, Qin W, et al. Raloxifene alleviates amyloid???induced cytotoxicity in HT22 neuronal cells via inhibiting oligomeric and fibrillar species formation[J]. Journal of biochemical and molecular toxicology. 2019.