TargetMol

GPP78

Product Code:
 
TAR-T15412
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15412-5mg5mg£850.00
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TAR-T15412-50mg50mg£1,661.00
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Quantity:
TAR-T15412-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effects.
CAS:
1202580-59-3
Formula:
C27H29N5O
Molecular Weight:
439.563
Pathway:
Autophagy
Purity:
0.98
SMILES:
O=C(CCCCCCCn1cc(nn1)-c1cccnc1)Nc1ccccc1-c1ccccc1
Target:
Autophagy

References

1. Colombano G, et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem. 2010 Jan 28;53(2):616-23. 2. Esposito E, et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation. 2012 Apr 10;9:66.