TargetMol

AG-024322

Product Code:
 
TAR-T14136
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14136-5mg5mg£470.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T14136-50mg50mg£2,143.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T14136-100mg100mg£2,801.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
AG-024322 is a potent ATP-competitive inhibitor of pan-CDK against cell cycle kinases CDK1, CDK2, and CDK4(Ki values in the 1-3 nM range)
CAS:
837364-57-5
Formula:
C23H20F2N6
Molecular Weight:
418.452
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5cc(F)cc(F)c5[nH]4)c3c2)c1C
Target:
CDK

References

1. Brown AP, et al. Toxicity and toxicokinetics of the cyclin-dependent kinase inhibitor AG-024322 in cynomolgus monkeys following intravenous infusion.Cancer Chemother Pharmacol. 2008 Nov;62(6):1091-101. 2. Jessen BA,et al. Peripheral white blood cell toxicity induced by broad spectrum cyclin-dependent kinase inhibitors.J Appl Toxicol. 2007 Mar-Apr;27(2):133-42. 3. Cathy C.?Zhang, et al. AG-024322 is a multi-targeted CDK inhibitor with potent antitumor activity?in vivo. Cellular and Molecular Biology 53: Cell Cycle Control and Cancer 1