TargetMol

WDR5-IN-1

Product Code:
 
TAR-T13334
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13334-5mg5mg£404.00
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TAR-T13334-50mg50mg£1,934.00
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Quantity:
TAR-T13334-100mg100mg£3,066.00
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This product comes from: United States.
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Further Information

Bioactivity:
WDR5-IN-1 is a potent and selective inhibitor of WD repeat domain 5 (WDR5) (Kd <0.02 nM), and also inhibits MLL1 histone methyltransferase (HMT) activity (IC50: 2.2 nM).
CAS:
2408842-51-1
Formula:
C30H31FN4O3
Molecular Weight:
514.601
Purity:
0.98
SMILES:
COc1cc(CN2CCc3c(cc(Cn4ccn(C)c4=N)cc3-c3ccc(F)cc3C)C2=O)cc(OC)c1

References

1. Tian J, et al.Discovery?and?Structure-Based?Optimization?of?Potent?and?Selective?WD?Repeat?Domain?5?(WDR5)?Inhibitors?Containing?a?Dihydroisoquinolinone?Bicyclic?Core.J Med Chem.?2020 Jan 23;63(2):656-675.