TargetMol

Propylthiouracil

Product Code:
 
TAR-T1309
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1309-25mg25mg£97.00
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TAR-T1309-50mg50mg£107.00
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TAR-T1309-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1309-100mg100mg£117.00
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TAR-T1309-200mg200mg£128.00
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TAR-T1309-500mg500mg£140.00
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Further Information

Bioactivity:
Propylthiouracil is a thiourea derivative with an antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triiodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.
CAS:
51-52-5
Formula:
C7H10N2OS
Molecular Weight:
170.23
Pathway:
Endocrinology/Hormones
Purity:
0.9994
SMILES:
CCCc1cc(=O)[nH]c(S)n1
Target:
Thyroid hormone receptor(THR)

References

1. Sener G, et al. J Endocrinol,2006, 189(2), 257-269. 2. Zamoner A, et al. J Mol Endocrinol,2008, 40(3), 125-135. 3. Liu C, et al. Environ Sci Technol,2011, 45(2), 769-775. 4. Pantos C, et al. J Endocrinol,2003, 178(3), 427-435. 5. Gilbert ME, et al. Brain Res Dev Brain Res,2003, 145(1), 19-29.