TargetMol

L-Canaline

Product Code:
 
TAR-T11802
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11802-5mg5mg£430.00
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TAR-T11802-50mg50mg£1,460.00
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TAR-T11802-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects. L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase.
CAS:
496-93-5
Formula:
C4H10N2O3
Molecular Weight:
134.135
Purity:
0.98
SMILES:
NOCC[C@H](N)C(O)=O

References

1. Bence AK, et al. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anticancer Drugs. 2002 Mar;13(3):313-20. 2. Rosenthal GA. L-canaline: a potent antimetabolite and anti-cancer agent from leguminous plants. Life Sci. 1997;60(19):1635-41. 3. Berger BJ. Antimalarial activities of aminooxy compounds. Antimicrob Agents Chemother. 2000 Sep;44(9):2540-2.