TargetMol

INT-767

Product Code:
 
TAR-T11661
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11661-5mg5mg£537.00
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TAR-T11661-50mg50mg£2,303.00
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Quantity:
TAR-T11661-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.
CAS:
1000403-03-1
Formula:
C25H43NaO6S
Molecular Weight:
494.66
Purity:
0.98
SMILES:
[Na+].CCC1C(O)C2C3CCC(C(C)CCOS([O-])(=O)=O)C3(C)CCC2C2(C)CCC(O)CC12

References

1. Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312. 2. Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.