TargetMol

gamma-Secretase Modulators

Product Code:
 
TAR-T11362
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11362-5mg5mg£470.00
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TAR-T11362-50mg50mg£2,087.00
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Quantity:
TAR-T11362-100mg100mg£3,131.00
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  • Further Information
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Further Information

Bioactivity:
gamma-Secretase Modulators is useful for Alzheimer's disease. IC50 value: Target: γ-secretase modulator.gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor.
CAS:
937812-80-1
Formula:
C26H24F3N3O3
Molecular Weight:
483.491
Purity:
0.98
SMILES:
[H][C@@]12CCC(=C/c3ccc(c(OC)c3)-n3cnc(C)c3)C(=O)N1[C@@H](COC2)c1cc(F)c(F)c(F)c1

References

1. Watahiki H, Yagishita S, Futai E, Ishiura S.CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of A?42-lowering ?-secretase modulators.Neurosci Lett. 2012 Sep 27;526(2):96-9. Epub 2012 Aug 23. 2. Wanngren J, Ottervald J, Parpal S, Portelius E, Str?mberg K, Borgeg?rd T, Klintenberg R, Jur?us A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlstr?m H.Second generation ?-secretase modulators exhibit different modulation of Notch ? 3. Wagner SL, Tanzi RE, Mobley WC, Galasko D.Potential Use of ?-Secretase Modulators in the Treatment of Alzheimer Disease.Arch Neurol. 2012 Jul 16:1-4. 4. Bulic B, Ness J, Hahn S, Rennhack A, Jumpertz T, Weggen S.Chemical Biology, Molecular Mechanism and Clinical Perspective of ?-Secretase Modulators in Alzheimer's Disease.Curr Neuropharmacol. 2011 Dec;9(4):598-622. 5. Kretner, Benedikt; Fukumori, Akio; Gutsmiedl, Amelie; Page, Richard M.; Luebbers, Thomas; Galley, Guido; Baumann, Karlheinz; Haass, Christian; Steiner, Harald. Attenuated A.beta.42 Responses to Low Potency .gamma.-Secretase Modulators Can Be Overcome for