TargetMol

EML4-ALK kinase inhibitor 1

Product Code:
 
TAR-T11184
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11184-1mg1mg£189.00
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TAR-T11184-5mg5mg£369.00
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TAR-T11184-1mL1 mL * 10 mM (in DMSO)£453.00
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TAR-T11184-10mg10mg£517.00
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TAR-T11184-25mg25mg£790.00
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TAR-T11184-50mg50mg£1,050.00
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TAR-T11184-100mg100mg£1,396.00
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TAR-T11184-500mg500mg£2,713.00
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Further Information

Bioactivity:
EML4-ALK kinase inhibitor 1 is a potent oral active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM.
CAS:
1373409-08-5
Formula:
C31H48N8O3
Molecular Weight:
580.76
Pathway:
Tyrosine Kinase/Adaptors|Angiogenesis
Purity:
0.9914
SMILES:
N(C=1C(C(N)=O)=NC(CC)=C(N[C@@H]2CC[C@@H](OC)CC2)N1)C3=CC(OC)=C(C=C3)N4CCC(CC4)N5CCN(C)CC5
Target:
ALK

References

1. Iikubo K, et al. Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1683-1692.