TargetMol

7-Chlorokynurenic acid

Product Code:
 
TAR-T10191L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T10191L-5mg5mg£101.00
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TAR-T10191L-10mg10mg£119.00
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TAR-T10191L-1mL1 mL * 10 mM (in DMSO)£124.00
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TAR-T10191L-25mg25mg£173.00
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TAR-T10191L-50mg50mg£267.00
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TAR-T10191L-100mg100mg£450.00
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TAR-T10191L-500mg500mg£863.00
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Further Information

Bioactivity:
7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.
CAS:
18000-24-3
Formula:
C10H6ClNO3
Molecular Weight:
223.61
Pathway:
Neuroscience
Purity:
0.9972
SMILES:
O=C(O)C=1N=C2C=C(Cl)C=CC2=C(O)C1
Target:
GluR; NMDAR

References

1. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50. 2. Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196. 3. Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32.