TargetMol

Bosutinib

Product Code:
 
TAR-T0152
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0152-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T0152-10mg10mg£111.00
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TAR-T0152-25mg25mg£121.00
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TAR-T0152-50mg50mg£149.00
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TAR-T0152-100mg100mg£189.00
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TAR-T0152-200mg200mg£211.00
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Further Information

Bioactivity:
Bosutinib is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.
CAS:
380843-75-4
Formula:
C26H29Cl2N5O3
Molecular Weight:
530.45
Pathway:
Cytoskeletal Signaling; Autophagy; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.999
SMILES:
COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Target:
Bcr-Abl; Src; Autophagy

References

1. Boschelli DH, et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem. 2001 Nov 8;44(23):3965-77. 2. Golas JM, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res. 2003 Jan 15;63(2):375-81. 3. Golas JM, et al. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res. 2005 Jun 15;65(12):5358-64.