TargetMol

Traxoprodil

Product Code:
 
TAR-TQ0233
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0233-25mg25mgEnquire
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TAR-TQ0233-50mg50mgEnquire
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TAR-TQ0233-5mg5mg£108.00
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TAR-TQ0233-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-TQ0233-10mg10mg£122.00
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This product comes from: United States.
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Further Information

Bioactivity:
Traxoprodil is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
CAS:
134234-12-1
Formula:
C20H25NO3
Molecular Weight:
327.424
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.9986
SMILES:
CC(C(O)c1ccc(O)cc1)N1CCC(O)(CC1)c1ccccc1
Target:
NMDAR; iGluR

References

Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45. Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14. Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9.