TargetMol

UNC0646

Product Code:
 
TAR-TQ0232
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0232-5mg5mg£117.00
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Quantity:
TAR-TQ0232-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-TQ0232-10mg10mg£153.00
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TAR-TQ0232-25mg25mg£225.00
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Quantity:
TAR-TQ0232-50mg50mg£345.00
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Quantity:
TAR-TQ0232-100mg100mg£470.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
CAS:
1320288-17-2
Formula:
C36H59N7O2
Molecular Weight:
621.915
Pathway:
Chromatin/Epigenetic
Purity:
1
SMILES:
COc1cc2c(NC3CCN(CC3)C3CCCCC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C
Target:
Histone Methyltransferase

References

Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.