TargetMol

Isolicoflavonol

Product Code:
 
TAR-TN1783
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1783-5mg5mg£511.00
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Further Information

Bioactivity:
Isolicoflavonol inhibits Human carboxylesterase 2 (hCES2A) which is a key target to ameliorate the intestinal toxicity triggered by irinotecan that causes severe diarrhea in 50%-80% of patients receiving this anticancer agent.
CAS:
94805-83-1
Formula:
C20H18O6
Molecular Weight:
354.358
Pathway:
Metabolism
Purity:
0.98
SMILES:
CC(C)=CCc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O
Target:
Lipid

References

Song YQ, et al. Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking-based virtual screening and fluorescence-based inhibition assays. Food Funct. 2021;12(1):162-176. Kinghorn AD, et al. Natural inhibitors of carcinogenesis. Planta Med. 2004 Aug;70(8):691-705.