TargetMol

Bractoppin

Product Code:
 
TAR-T8873
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8873-1mg1mg£115.00
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TAR-T8873-2mg2mg£133.00
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TAR-T8873-5mg5mg£172.00
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TAR-T8873-1mL1 mL * 10 mM (in DMSO)£189.00
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TAR-T8873-10mg10mg£237.00
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TAR-T8873-25mg25mg£430.00
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TAR-T8873-50mg50mg£599.00
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TAR-T8873-100mg100mg£824.00
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Further Information

Bioactivity:
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
CAS:
2290527-07-8
Formula:
C25H23FN4O
Molecular Weight:
414.484
Pathway:
; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.9965
SMILES:
Fc1ccccc1CN1CCN(CC1)C(=O)c1ccc2[nH]c(nc2c1)-c1ccccc1
Target:
DNA/RNA Synthesis

References

Periasamy J , Kurdekar V , Jasti S , et al. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling[J]. Cell Chemical Biology, 2018:S245194561830076X.