TargetMol

PF-543 hydrochloride

Product Code:
 
TAR-T8840
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8840-1mg1mg£97.00
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TAR-T8840-5mg5mg£127.00
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TAR-T8840-10mg10mg£181.00
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TAR-T8840-25mg25mg£270.00
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TAR-T8840-50mg50mg£340.00
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Quantity:
TAR-T8840-100mg100mg£483.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
CAS:
1706522-79-3
Formula:
C27H32ClNO4S
Molecular Weight:
502.07
Pathway:
GPCR/G Protein; Autophagy; Apoptosis
Purity:
0.9992
SMILES:
Cl.Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1
Target:
Apoptosis; S1P Receptor; Autophagy; LPL Receptor

References

Zhang L, Yi Y, Wang T, et al.25-Hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.Veterinary Microbiology.2023: 109668. Schnute ME, McReynolds MD, Kasten T, et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012;444(1):79-88. doi:10.1042/BJ20111929