TargetMol

GMB-475

Product Code:
 
TAR-T8488
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8488-1mg1mg£141.00
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TAR-T8488-5mg5mg£239.00
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TAR-T8488-1mL1 mL * 10 mM (in DMSO)£350.00
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TAR-T8488-10mg10mg£367.00
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TAR-T8488-25mg25mg£570.00
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TAR-T8488-50mg50mg£781.00
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TAR-T8488-100mg100mg£1,026.00
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TAR-T8488-500mg500mg£2,022.00
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This product comes from: United States.
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Further Information

Bioactivity:
GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein
CAS:
2490599-18-1
Formula:
C43H4F3NOS
Molecular Weight:
861.93
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
Purity:
0.9878
SMILES:
CC1=C(SC=N1)C1=CC=C(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCOC2=CC=C(C=C2)C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)C(C)(C)C)C=C1
Target:
Bcr-Abl

References

Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.