TargetMol

Regorafenib Hydrochloride

Product Code:
 
TAR-T8402
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8402-5mg5mg£95.00
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TAR-T8402-10mg10mg£109.00
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TAR-T8402-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T8402-50mg50mg£152.00
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TAR-T8402-100mg100mg£191.00
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This product comes from: United States.
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Further Information

Bioactivity:
Regorafenib Hydrochloride is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
CAS:
835621-07-3
Formula:
C21H16Cl2F4N4O3
Molecular Weight:
519.28
Pathway:
Autophagy; Apoptosis; MAPK; Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
1
SMILES:
Cl.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1
Target:
Raf; VEGFR; c-RET; PDGFR; Autophagy

References

Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228(2), 292-297. Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255.