TargetMol

Epiberberine chloride

Product Code:
 
TAR-T8306
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8306-5mg5mg£132.00
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TAR-T8306-10mg10mg£149.00
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TAR-T8306-50mg50mg£360.00
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Further Information

Bioactivity:
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).
CAS:
889665-86-5
Formula:
C20H18ClNO4
Molecular Weight:
371.82
Pathway:
Metabolism; Neuroscience; NF-κb; Immunology/Inflammation
Purity:
0.98
SMILES:
[Cl-].COc1cc2CC[n+]3cc4c5OCOc5ccc4cc3-c2cc1OC
Target:
Reactive Oxygen Species; Beta-Secretase; BACE; AChR; AChE

References

Ma H, et al. Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice. Drug Dev Res. 2016 Jun;77(4):163-70. Jung HA, et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8. Choi JS, et al. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPK?/Akt pathways. Arch Pharm Res. 2015 Dec;38(12):2153-62.