TargetMol

PD146176

Product Code:
 
TAR-T7530
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7530-5mg5mg£103.00
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TAR-T7530-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T7530-10mg10mg£130.00
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TAR-T7530-25mg25mg£189.00
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TAR-T7530-50mg50mg£291.00
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TAR-T7530-100mg100mg£458.00
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Further Information

Bioactivity:
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
CAS:
4079-26-9
Formula:
C15H11NS
Molecular Weight:
237.32
Pathway:
Apoptosis; Cell Cycle/Checkpoint; Metabolism; Autophagy
Purity:
0.9977
SMILES:
C1Sc2ccccc2-c2[nH]c3ccccc3c12
Target:
Ferroptosis; Lipoxygenase; Autophagy

References

Di Meco A, et al. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81(2):92-100. Sendobry SM, et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol. 1997;120(7):1199-1206. Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139(1):201]. Atherosclerosis. 1998;136(2):203-216.