TargetMol

Eupatorin

Product Code:
 
TAR-T7032
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T7032-1mg1mg£103.00
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Further Information

Bioactivity:
Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is mediated by both the extrinsic and the intrinsic apoptotic pathways and through a mechanism dependent on reactive oxygen species generation. Eupatorin also has meaningful anti-inflammatory property.
CAS:
855-96-9
Formula:
C18H16O7
Molecular Weight:
344.319
Pathway:
; Metabolism
Purity:
0.9809
SMILES:
COc1ccc(cc1O)-c1cc(=O)c2c(O)c(OC)c(OC)cc2o1
Target:
P45

References

Est?vez S, et al. Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway.[J]. Plos One, 2014, 9(11):e112536. Laavola M, et al. Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation[J]. Planta Medica, 2012, 78(08):779-786. Dole?kov? I, et al. Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus, leaves[J]. Fitoterapia, 2012, 83(6):12000-12007. Androutsopoulos V, et al. Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism[J]. Breast Cancer Research,10,3(2008-05-02), 2008, 10(3):R39.