TargetMol

Fludarabine Phosphate

Product Code:
 
TAR-T6501
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6501-5mg5mg£98.00
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TAR-T6501-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T6501-10mg10mg£114.00
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TAR-T6501-25mg25mg£140.00
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TAR-T6501-50mg50mg£164.00
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TAR-T6501-100mg100mg£186.00
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TAR-T6501-200mg200mg£232.00
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Further Information

Bioactivity:
Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.
CAS:
75607-67-9
Formula:
C10H13FN5O7P
Molecular Weight:
365.214
Pathway:
DNA Damage/DNA Repair; Cell Cycle/Checkpoint; Apoptosis
Purity:
0.98
SMILES:
Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
Target:
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis

References

Avramis VI, et al. Cancer Res, 1982, 42(7), 2587-2591. Huang P, et al, J Biol Chem, 1990, 265(27), 16617-16625. Umbach GE, et al. Invest New Drugs, 1984, 2(3), 263-265.