TargetMol

AMG 517

Product Code:
 
TAR-T6379
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6379-5mg5mg£108.00
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TAR-T6379-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-T6379-10mg10mg£142.00
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TAR-T6379-25mg25mg£229.00
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TAR-T6379-50mg50mg£369.00
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TAR-T6379-100mg100mg£517.00
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Further Information

Bioactivity:
AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1.
CAS:
659730-32-2
Formula:
C20H13F3N4O2S
Molecular Weight:
430.41
Pathway:
Membrane transporter/Ion channel
Purity:
0.9985
SMILES:
CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
Target:
TRP/TRPV Channel

References

Zhang M, Jia X, Cheng C, et al.Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.Acta Pharmacologica Sinica.2023: 1-12. Gavva NR, et al. J Pharmacol Exp Ther, 2007, 323(1), 128-137. Pan X, Li R, Guo H, et al. Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1[J]. Frontiers in Pharmacology. 2021, 11: 2233. Gavva NR, et al. Pain, 2008, 136(1-2), 202-210. Pan X, Li R, Guo H, et al. Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1. Frontiers in Pharmacology. 2021 Jan 13;11:539261. doi: 10.3389/fphar.2020.539261. eCollection 2020.