TargetMol

URMC-099

Product Code:
 
TAR-T6057
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6057-5mg5mg£112.00
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Quantity:
TAR-T6057-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T6057-10mg10mg£134.00
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TAR-T6057-25mg25mg£185.00
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TAR-T6057-50mg50mg£258.00
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Quantity:
TAR-T6057-100mg100mg£389.00
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Further Information

Bioactivity:
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
CAS:
1229582-33-5
Formula:
C27H27N5
Molecular Weight:
421.548
Pathway:
Chromatin/Epigenetic; Metabolism; Tyrosine Kinase/Adaptors; Autophagy; Stem Cells; DNA Damage/DNA Repair; Cytoskeletal Signaling; MAPK; Angiogenesis; Cell Cycle/Checkpoint
Purity:
0.9932
SMILES:
CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Target:
ROCK; MLK; VEGFR; SGK; DNA Alkylation; Trk receptor; c-Met/HGFR; LRRK2; MEK; IGF-1R; Syk; Bcr-Abl; CDK; Src; Aurora Kinase; Autophagy

References

Polesskaya O, et al. Mol Immunol. 2014, 58(2), 214-222. Goodfellow VS, et al. J Med Chem. 2013, 56(20), 8032-8048. Marker DF, et al. J Neurosci. 2013, 33(24), 91998-1202010.