TargetMol

Maraviroc

Product Code:
 
TAR-T6016
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6016-5mg5mg£108.00
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TAR-T6016-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T6016-10mg10mg£140.00
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TAR-T6016-25mg25mg£201.00
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TAR-T6016-50mg50mg£301.00
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Quantity:
TAR-T6016-100mg100mg£486.00
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TAR-T6016-200mg200mg£606.00
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Quantity:
TAR-T6016-500mg500mg£914.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction.
CAS:
376348-65-1
Formula:
C29H41F2N5O
Molecular Weight:
513.678
Pathway:
Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
Purity:
0.9955
SMILES:
CC(C)c1nnc(C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1
Target:
HIV Protease; CCR

References

Wu Q, Cui L, Ma W, et al.A novel small-molecular CCR5 antagonist promotes neural repair after stroke.Acta Pharmacologica Sinica.2023: 1-13. Horie M, Takagane K, Itoh G, et al.Exosomes secreted by ST3GAL5 high cancer cells promote peritoneal dissemination by establishing a pre?metastatic microenvironment.Molecular Oncology.2023 Dorr P, et al. Antimicrob Agents Chemother. 2005, 49(11), 4721-4732. Tan S, Li J Q, Cheng H, et al. The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1[J]. Journal of Biological Chemistry. 2019: jbc. RA118. 006797. Yang J Y, Zhang J, Lu R, et al. T cell?derived exosomes induced macrophage inflammatory protein?1?/? drive the trafficking of CD8+ T cells in oral lichen planus. Journal of Cellular and Molecular Medicine. 2020 Neff CP, et al. PLoS One. 2011, 6(6), e20209. Tan S, Li J Q, Cheng H, et al. The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1. Journal of Biological Chemistry. 2019: jbc. RA118. 006797 Yang J Y, Zhang J, Lu R, et al. T cell?derived exosomes induced macrophage inflammatory protein?1?/? drive the trafficking of CD8+ T cells in oral lichen planus[J]. Journal of cellular and molecular medicine. 2020