TargetMol

NAcM-OPT

Product Code:
 
TAR-T5374
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5374-5mg5mg£107.00
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Quantity:
TAR-T5374-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T5374-10mg10mg£128.00
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TAR-T5374-25mg25mg£193.00
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TAR-T5374-50mg50mg£251.00
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Quantity:
TAR-T5374-100mg100mg£374.00
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Quantity:
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Further Information

Bioactivity:
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 ?IC50: 79 nM).
CAS:
2089293-61-6
Formula:
C23H29Cl2N3O
Molecular Weight:
434.41
Pathway:
Ubiquitination; Metabolism
Purity:
0.98
SMILES:
CCCCN1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Target:
E1/E2/E3 Enzyme; NEDD8

References

Scott DC, et al. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat Chem Biol. 2017 Aug;13(8):850-857. Hammill JT, et al. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61(7):2694-2706.