TargetMol

C-176

Product Code:
 
TAR-T5154
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5154-5mg5mg£102.00
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TAR-T5154-1mL1 mL * 10 mM (in DMSO)£105.00
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TAR-T5154-10mg10mg£128.00
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TAR-T5154-25mg25mg£149.00
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TAR-T5154-50mg50mg£181.00
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TAR-T5154-100mg100mg£269.00
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TAR-T5154-200mg200mg£365.00
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TAR-T5154-500mg500mg£549.00
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This product comes from: United States.
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Further Information

Bioactivity:
C-176 is a strong, covalent mouse STING inhibitor
CAS:
314054-00-7
Formula:
C11H7IN2O4
Molecular Weight:
358.091
Pathway:
Immunology/Inflammation
Purity:
0.9997
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(I)cc1
Target:
STING

References

Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. Duan H, et al. Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression. Bioorg Med Chem. 2015 Aug 1;23(15):4514-21. Jin L, Yu B, Wang H, et al.STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.Free Radical Biology and Medicine.2023 Liu X, Cen X, Wu R, et al.ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade.Nature Communications.2023, 14(1): 4066.