TargetMol

Praeruptorin B

Product Code:
 
TAR-T4S1421
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via the PXR-mediated pathway.
CAS:
73069-28-0
Formula:
C24H26O7
Molecular Weight:
426.465
Pathway:
Metabolism; Membrane transporter/Ion channel
Purity:
0.98
SMILES:
CC=C(C)C(=O)O[C@@H]1[C@H](OC(=O)C(C)=C/C)C(C)(C)Oc2ccc3ccc(=O)oc3c12
Target:
NPC1L1; Fatty Acid Synthase

References

Liu X, et al. The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B. Phytother Res. 2016 Nov;30(11):1872-1878. Zu-Guo Zheng, et al. Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway. RSC Adv., 2018, 8, 354?366