TargetMol

Glaucocalyxin A

Product Code:
 
TAR-T4S0498
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T4S0498-5mg5mg£151.00
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Quantity:
TAR-T4S0498-1mL1 mL * 10 mM (in DMSO)£158.00
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Further Information

Bioactivity:
1. Glaucocalyxin A-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GP? pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.
CAS:
79498-31-0
Formula:
C20H28O4
Molecular Weight:
332.44
Pathway:
Apoptosis; Proteases/Proteasome; PI3K/Akt/mTOR signaling; Cytoskeletal Signaling
Purity:
0.9955
SMILES:
CC1(C)[C@H]2C[C@@H](O)[C@@]34[C@H](O)[C@@H](CC[C@H]3[C@]2(C)CCC1=O)C(=C)C4=O
Target:
Apoptosis; Akt; Caspase; PI3K

References

Hou X, Xu G, Wang Z, et al. Glaucocalyxin A alleviates LPS-mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation. International Immunopharmacology. 2020, 81: 106271 Xiao X , Cao W , Jiang X , et al. Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells[J].2013, 45(11):946-52. Hou X, Xu G, Wang Z, et al. Glaucocalyxin A alleviates LPS-mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation[J]. International Immunopharmacology. 2020, 81: 106271.