TargetMol

SB297006

Product Code:
 
TAR-T4674
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4674-5mg5mg£122.00
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Quantity:
TAR-T4674-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T4674-10mg10mg£148.00
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TAR-T4674-25mg25mg£230.00
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TAR-T4674-50mg50mg£367.00
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Quantity:
TAR-T4674-100mg100mg£511.00
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Quantity:
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Further Information

Bioactivity:
SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).
CAS:
58816-69-6
Formula:
C18H18N2O5
Molecular Weight:
342.35
Pathway:
Microbiology/Virology; Immunology/Inflammation
Purity:
0.9965
SMILES:
[C@@H](CC1=CC=C(N(=O)=O)C=C1)(NC(=O)C2=CC=CC=C2)C(OCC)=O
Target:
CCR

References

Mori, A., Ogawa, K., Someya, K., et al. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int. Immunol. 19(8), 913-921 (2007).