TargetMol

Olodanrigan

Product Code:
 
TAR-T4431
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4431-2mg2mg£104.00
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TAR-T4431-5mg5mg£125.00
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TAR-T4431-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T4431-10mg10mg£161.00
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TAR-T4431-25mg25mg£229.00
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TAR-T4431-50mg50mg£360.00
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Quantity:
TAR-T4431-100mg100mg£500.00
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Further Information

Bioactivity:
EMA401, a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA401 blocks p38, p42/p44 mitogen-activated protein kinase (MAPK) activation, neurite outgrowth in adult rat DRG neurons, and sensitization of adult rat and human DRG neurons induced by AngII. It inhibits capsaicin responses in cultured hDRG neurons.
CAS:
1316755-16-4
Formula:
C32H29NO5
Molecular Weight:
507.58
Pathway:
Endocrinology/Hormones
Purity:
0.9413
SMILES:
COc1ccc2CN([C@@H](Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1
Target:
RAAS

References

Rice A S C, Dworkin R H, McCarthy T D, et al. EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 Clinicalal trial[J]. The Lancet, 2014, 383(9929): 1637-1647. Anand U, Yiangou Y, Sinisi M, et al. Mechanisms underlying Clinicalal efficacy of Angiotensin II type 2 receptor (AT 2 R) antagonist EMA401 in neuropathic pain: Clinicalal tissue and in vitro studies[J]. Molecular pain, 2015, 11(1): 38.