TargetMol

MS049 2HCl (1502816-23-0(free base))

Product Code:
 
TAR-T4393
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4393-2mg2mg£96.00
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TAR-T4393-1mL1 mL * 10 mM (in DMSO)£108.00
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TAR-T4393-5mg5mg£108.00
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TAR-T4393-10mg10mg£132.00
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TAR-T4393-25mg25mg£201.00
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TAR-T4393-50mg50mg£318.00
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Further Information

Bioactivity:
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 μM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.
CAS:
T4393
Formula:
C15H26Cl2N2O
Molecular Weight:
321.28
Pathway:
Chromatin/Epigenetic
Purity:
0.999
SMILES:
Cl.Cl.CNCCN1CCC(CC1)OCc2ccccc2
Target:
Histone Methyltransferase

References

Shen Y, etal. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6[J]. Journal of Medicinal Chemistry, 2016, 59(19):9124-9139.