TargetMol

ZNL 02-096

Product Code:
 
TAR-T41163
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41163-1mg1mg£352.00
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Quantity:
TAR-T41163-5mg5mg£736.00
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Quantity:
TAR-T41163-10mg10mg£978.00
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TAR-T41163-25mg25mg£1,348.00
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Quantity:
TAR-T41163-50mg50mg£1,661.00
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Quantity:
TAR-T41163-100mg100mg£2,079.00
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Quantity:
TAR-T41163-500mg500mg£4,006.00
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Further Information

Bioactivity:
ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC?) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide. ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cellsin vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.
CAS:
2414418-49-6
Formula:
0
Molecular Weight:
0
Pathway:
Cell Cycle/Checkpoint|Apoptosis
Purity:
0.98
SMILES:
0
Target:
Wee1|Apoptosis

References

Nathanael S G, et al. Degraders of wee1 kinase. WO2020069105A1.