TargetMol

3-TYP

Product Code:
 
TAR-T4108
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4108-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-T4108-5mg5mg£112.00
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TAR-T4108-10mg10mg£142.00
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TAR-T4108-25mg25mg£213.00
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TAR-T4108-50mg50mg£291.00
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TAR-T4108-100mg100mg£468.00
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TAR-T4108-500mg500mg£970.00
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This product comes from: United States.
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Further Information

Bioactivity:
3-TYP is a selective SIRT3 inhibitor.
CAS:
120241-79-4
Formula:
C7H6N4
Molecular Weight:
146.153
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
1
SMILES:
c1[nH]nnc1-c1cccnc1
Target:
Sirtuin

References

Zhai M, et al. Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. J Pineal Res. 2017 Sep;63(2). Lahiri T, Brambilla L, Andrade J, et al. Mitochondrial STAT3 regulates antioxidant gene expression through complex I?derived NAD in triple negative breast cancer[J]. Molecular Oncology. 2021 Lahiri T, Brambilla L, Andrade J, et al. Mitochondrial STAT3 regulates antioxidant gene expression through complex I?derived NAD in triple negative breast cancer. Molecular Oncology. 2021 May;15(5):1432-1449. doi: 10.1002/1878-0261.12928. Epub 2021 Apr 10. Pi H, et al. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015;11(7):1037-51 Xue K H, Jiang Y F, Bai J Y, et al.Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect.Redox Report.2023, 28(1): 2251234. Zhang Y, Gao F, Gong H, et al.Intermittent fasting attenuates obesity-related atrial fibrillation via SIRT3-mediated insulin resistance mitigation.Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease.2023: 166638.