TargetMol

AFN-1252 tosylate

Product Code:
 
TAR-T4105L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T4105L-5mg5mg£850.00
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Further Information

Bioactivity:
AFN-1252 tosylate is an enoyl-ACP Reductase inhibitor.
CAS:
1047981-31-6
Formula:
C29H29N3O6S
Molecular Weight:
547.63
Purity:
0.98
SMILES:
Cc1ccc(cc1)S(O)(=O)=O.CN(Cc1oc2ccccc2c1C)C(=O)C=Cc1cnc2NC(=O)CCc2c1

References

Banevicius MA, Kaplan N, Hafkin B, Nicolau DP. Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model. J Chemother. 2013 Feb;25(1):26-31. doi: 10.1179/1973947812Y.0000000061. PubMed PMID: 23433441; PubMed Central PMCID: PMC3558988. Kaplan N, Garner C, Hafkin B. AFN-1252 in vitro absorption studies and pharmacokinetics following microdosing in healthy subjects. Eur J Pharm Sci. 2013 Nov 20;50(3-4):440-6. doi: 10.1016/j.ejps.2013.08.019. Epub 2013 Aug 27. Erratum in: Eur J Pharm Sci. 2014 Feb 14;52:223. PubMed PMID: 23988847. Rao KN, Lakshminarasimhan A, Joseph S, Lekshmi SU, Lau MS, Takhi M, Sreenivas K, Nathan S, Yusof R, Abd Rahman N, Ramachandra M, Antony T, Subramanya H. AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei--Crystal structure, mode of action, and biological activity. Protein Sci. 2015 May;24(5):832-40. doi: 10.1002/pro.2655. Epub 2015 Apr 2. PubMed PMID: 25644789; PubMed Central PMCID: PMC4420531. Yao J, Maxwell JB, Rock CO. Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). J Biol Chem. 2013 Dec 20;288(51):36261-71. doi: 10.1074/jbc.M113.512905. Epub 2013 Nov 4. PubMed PMID: 24189061; PubMed Central PMCID: PMC3868742.