TargetMol

CAY10602

Product Code:
 
TAR-T4062
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4062-5mg5mg£108.00
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TAR-T4062-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T4062-10mg10mg£116.00
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TAR-T4062-25mg25mg£148.00
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TAR-T4062-50mg50mg£217.00
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TAR-T4062-100mg100mg£332.00
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Further Information

Bioactivity:
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
CAS:
374922-43-7
Formula:
C22H15FN4O2S
Molecular Weight:
418.45
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
1
SMILES:
Nc1c(c2nc3ccccc3nc2n1-c1ccc(F)cc1)S(=O)(=O)c1ccccc1
Target:
Sirtuin

References

Nayagam VM, et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen. 2006 Dec;11(8):959-67. H?ppner S, et al. Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):35-50.